Determination of Clocapramine in Plasma by High-performance Liquid Chromatography

Abstract

A simple high-performance liquid chromatographic method for determination of the psychotropic drug, clocapramine, in plasma is described. The method permits the accurate determination of the drug in plasma as low as 5ng/ml and is suited for monitoring the drug in the therapeutic dose range and for the investigation of the bioavailabilities of the drug preparations. Simultaneous determination of clocapramine and carpipramine, another psychotropic drug, is possible.