SIMPLE AND RAPID TARGET SCREENING OF CONTAMINANTS OF EMERGING CONCERN BY LC-QTOF/MS AND THE CHEMICAL PROFILING ANALYSES IN THE KISO THREE RIVERS BASIN

Abstract

 This study was aimed to develop the methods for target screening (TS) of contaminants of emerging concern (CECs) by LC-QTOF-MS in consideration with its simplicity and rapidness. In the TS database (TS-DB), measured m/z values of fragment ions and retention time index were applied and registered. For the TS analyses condition, mass error range (precursor ion: 10 ppm, fragment ion: 50 ppm) and retention time range (ΔRT=±1.0 min) were applied. By the developed TS-DB with 102 types of CECs and the TS methods, TS was conducted for 15 river water samples in the Kiso Three Rivers Basin. As a result, 30 types of CECs were detected. By the chemical profiling analyses, the occurrences of linear alkyl benzene sulfonates (LASs), Pharma-ceutical and Personal Care Products (PPCPs) and Perfluorinated substances (PFASs) were demonstrated for each of Ibi-River, Nagara-River, Kiso-River and their tributaries. This study indicated that TS results together with usage information and the relative detected intensity may achive in understanding the occurrences and characteristics of the chemical profiles in water environment.