Abstract
Salmonella is one of the gram negative intracellular pathogens. The immune response to Salmonella includes innate immunity and adaptive immunity. The intestinal epithelium, neutrophil, macrophage, dendritic cell, NK cell, NK T cell and γδ T cell take important part in former process, and antigen specific T cell and B cell take part in the later process.
Macrophages and dendritic cells increase in number early after Salmonella infection and produce variety of cytokines. Especially, IL-12, IL-15 and IL-18 play important roles in protection against Salmonella infection, proliferation of NK cell, NKT cell and γδ T cell, producing IFN-γ, in addition, IL-12 and IL-18 induce IFN-γ production by Th1 cells and adaptive immune response.
