Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
Review Articles
Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis
Naoto TAMURA, Kazuhiko HARUTA
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Keywords: Phosphoinositide-3 kinase (PI3K), PI3K inhibitor, rheumatoid arthritis, therapy, ZSTK474
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2007 Volume 30 Issue 5 Pages 369-374

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Abstract
  Activation of PI3K is a key step of intracellular signaling involved in many cellular functions. PI3K inhibitors have shown anti-rheumatic effects on arthritis model in mice. PI3K is a potential therapeutic target of rheumatoid arthritis
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© 2007 The Japan Society for Clinical Immunology
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