Successful combination therapy with corticosteroids, biweekly intravenous pulse cyclophosphamide and cyclosporin A for acute interstitial pneumonia in patients with dermatomyositis : report of three cases

Akitake SUZUKI; Norikazu SHOJI; Eigo KIKUCHI; Kazuaki UEKUBO; Naoko AOKI; Yui SONODA; Hideyuki TORIGAI; Hiroyuki YAMASHITA; Kentaro FUJITA; Takahiro OKAI

doi:10.2177/jsci.36.122

Case Report

Successful combination therapy with corticosteroids, biweekly intravenous pulse cyclophosphamide and cyclosporin A for acute interstitial pneumonia in patients with dermatomyositis : report of three cases

Akitake SUZUKI, Norikazu SHOJI, Eigo KIKUCHI, Kazuaki UEKUBO, Naoko AOKI, Yui SONODA, Hideyuki TORIGAI, Hiroyuki YAMASHITA, Kentaro FUJITA, Takahiro OKAI

Author information

Akitake SUZUKI
Center for Rheumatology and Joint Surgery, Kawakita General Hospital
Norikazu SHOJI
Center for Rheumatology and Joint Surgery, Kawakita General Hospital
Eigo KIKUCHI
Center for Rheumatology and Joint Surgery, Kawakita General Hospital
Kazuaki UEKUBO
Center for Rheumatology and Joint Surgery, Kawakita General Hospital
Naoko AOKI
Center for Rheumatology and Joint Surgery, Kawakita General Hospital
Yui SONODA
Center for Rheumatology and Joint Surgery, Kawakita General Hospital
Hideyuki TORIGAI
Center for Rheumatology and Joint Surgery, Kawakita General Hospital
Hiroyuki YAMASHITA
Department of Rheumatology, National Center for Global Health and Medicine
Kentaro FUJITA
Department of Rheumatology, National Center for Global Health and Medicine
Takahiro OKAI
Center for Rheumatology and Joint Surgery, Kawakita General Hospital

Keywords: Acute Interstitial Pneumonia, Dermatomyositis, Diffuse alveolar damage, Biweekly Intravenous pulse cyclophosphamide, Cyclosporine A

JOURNAL FREE ACCESS

2013 Volume 36 Issue 2 Pages 122-128

DOI https://doi.org/10.2177/jsci.36.122

Details

Abstract

We report three patients with dermatomyositis (DM) complicated with acute interstitial pneumonia (AIP). All of them complained of fever and acutely worsening dyspnea and were treated immediately by combination therapies with pulse therapy with methylprednisone (mPSL) followed by corticosteroids, biweekly intravenous pulse cyclophosphamide (IVCY) and cyclosporine A (CSA). They recovered rapidly soon after an initiation of this combination regimen. Early intervention with aggressive combination therapy is life-saving for the treatment of AIP in patients with DM.

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