Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
Review Articles
Autophagy in autoimmune disease
Toshiyuki BOHGAKITatsuya ATSUMI
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JOURNAL FREE ACCESS

2014 Volume 37 Issue 3 Pages 125-132

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Abstract
  Cell death process can be involved in the development, differentiation, inflammation, immunity and tumorigenesis. Molecular mechanism of apoptotic cell death has been unveiled while molecular mechanisms of the other programmed cell death, especially necroptosis and autophagy, also have been elucidated. Autophagy is a highly conserved lysosome-mediated catabolic process and a homeostatic process to degrade unnecessary or dysfunctional cellular organelles and to recycle nutrients. The relation between autophagy and human disease has been reported. Here, we describe about the role of autophagy in autoimmune disease.
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© 2014 The Japan Society for Clinical Immunology
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