Resident memory T cells in mouse and human

Abstract

  Recent researches are revealing the importance of a new subset of memory T cells called resident memory T cells (T_RM^s). Once they enter the tissues according to their tissue-homing receptors, TRMs do not go back to circulation and stay in the same tissues for a long time. These T cells are defined as expressing CD69 and/or CD103, and are known to show strong effector functions. It is considered that T_RM^s have an important role against infection in barrier tissues such as GI tract, skin, respiratory system and reproductive tract. Furthermore, recent reports indicate their roles in organ-specific chronic inflammatory disorders, autoimmune disorders and tumor immunology even in non-barrier tissues such as central nerve system, lymphatic tissue, liver, kidney, pancreas and joint. Here in this session, the author organized what have been known about T_RM both in mouse and human, including the development, functional activities and relation of T_RM to disease manifestation, for the detailed understanding of this fraction.