A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis

Tohru MICHITSUJI; Yoshiro HORAI; Ayaka SAKO; Taro ASANO; Nozomi IWANAGA; Yasumori IZUMI; Atsushi KAWAKAMI

doi:10.2177/jsci.40.467

Case Reports

A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis

Tohru MICHITSUJI, Yoshiro HORAI, Ayaka SAKO, Taro ASANO, Nozomi IWANAGA, Yasumori IZUMI, Atsushi KAWAKAMI

Author information

Tohru MICHITSUJI
Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center
Yoshiro HORAI
Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center
Department of Rheumatology, National Hospital Organization Nagasaki Medical Center
Clinical Research Center, National Hospital Organization Nagasaki Medical Center
Ayaka SAKO
Department of Endocrinology and Metabolism, National Hospital Organization Nagasaki Medical Center
Taro ASANO
Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center
Nozomi IWANAGA
Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center
Department of Rheumatology, National Hospital Organization Nagasaki Medical Center
Yasumori IZUMI
Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center
Atsushi KAWAKAMI
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences

Keywords: chronic thyroiditis, proteinase-3 antineutrophil cytoplasmic antibody, mixed connective tissue disease, slowly progressive type 1 diabetes mellitus

JOURNAL FREE ACCESS

2017 Volume 40 Issue 6 Pages 467-470

DOI https://doi.org/10.2177/jsci.40.467

Details

Abstract

A female in her sixties with slowly progressive type 1 diabetes mellitus (SPT1DM) and chronic thyroiditis was referred to our rheumatology department with swelling in her fingers. A prominent atherosclerotic lesion was revealed upon brain magnetic resonance imaging, and she was found to have mixed connective tissue disease (MCTD) positive for proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA). This rare case of MCTD accompanying SPT1DM and PR3-ANCA suggested that a synergy between MCTD and PR3-ANCA triggers atherosclerosis.

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