Abstract
Dipeptidyl aminopeptidase IV (DAP IV) has been demonstrated localizing in certain human T cell. In vitro mitogen stimulations (PHA, Con A and PWM) was employed to assess possible participation of lymphocyte DAP IV in immune responses.
In healthy human peripheral lymphocytes, mitogen stimulations produced a marked increase in DAP IV activities; and similar increase was observed also in culture supernatant. In addition, those phenomena paralleled with increase in released soluble IL-2 receptor.
The principal action of DAP IV remained unknown, but it might, with its connection to production of IL-2 receptor, be part of a correlating mechanism having to do with an immune regulatory system.
Clinical data from the patients with Behcet's disease, rheumatoid arthritis and systemic lupus erythematosus were discussed in a comparable manner.
