Abstract
It has been reported that injection of Transfer Factor (TF) enhances cellular immune reactions not only in patients with a variety of immunodeficiency but also bronchial asthma and atopic dermatitis. We studied the effects of oral administration of TF on nine patients with intractable atopic dermatitis and two patients with recurrent aphthous stomatitis having a dietry link. All of them showed somewhat decreased cellular immunity. Clinical symptoms of these disorders were prominently improved following the oral administration of TF. However, the interval before the appearence of effectiveness varied in each case from 1 time administration to 5 times. TF induced increased serum levels of IgG and IgA immunoglobulin. On the other hand this therapy reduced serum levels of antigen specific IgG antibodies. Our results suggest that oral administration of TF is as effective as injection therapy to control the symptoms of children with intractable atopic dermatitis and recurrent aphthous stomatitis having some decreased cellular immunity.
