Abstract
A 26-year-old female patient of mixed connective tissue disease (MCTD) associated with urticarial vasculitis was reported here. Early symptoms of the case were Raynaud's phenomenon, sausage fingers, slight fever, facial eruption and abnormal high levels of CPK 401 U/ml and anti-ENA antibody (312, 500) in February 1978.
While she had been treated with 10mg prednisolone a day, she noticed systemic urticarialike eruption associated with hypocomplementemia in September 1984. She was readmitted for further examination of skin eruptions. Skin biopsy findings showed the leucocytoclastic vasculitis.
Then 60mg prednisolone a day could control urticarial vasculitis for the first month.
It is well known that urticarial vasculitis is usually complicated with systemic lupus erythematosus, but urticarial vasculitis would be scarcely associated with MCTD. High titer of anti-RNP antibody has been suggested for the significant pathogenesis. As the case present here was not clinically active, more detailed studies are required to know the pathogenesis of coexistence of urticarial vasculitis and MCTD.
