Abstract
We report a case of mixed connective tissue disease (MCTD) who had necrotizing lymphadenitis and aseptic meningitis in the clinical course. The patient was thirteen year old boy. He visited our hospital with chief complaint of fever of unknown origin and clinical studies revealed liver disfunction. After that he showed Raynaud's phenomenon, swollen hands and arthralgia. The titer of antibody to antinuclear antigen (ANA) and nuclear ribonucleoprotein (nRNP) elevated gradually and the diagnosis of MCTD was made.
It was suspected that necrotizing lymphadenitis had some relation to MCTD, but aseptic meningitis occured by chance owing to a viral infection.
