Abstract
The two cases with malignant liver tumors were investigated to show the in vivo distribution of tumor-infiltrating lymphocytes (TIL) transferred via hepatic artery.
Recombinant interleukin-2 and anti-CD3 antibody activated TIL, labeled with 111In, were injected into the hepatic artery through an Infuse-A-Port. In a patient with hepatocellular carcinoma, the radioactivities in the area corresponding to tumor site were significantly higher than those in the non-cancerous portion of the liver, at least, until 48 hours after injection. Similar result was observed in a patient with metastatic liver tumors from rectal cancer.
This preliminary result indicates that an intra-arterial transfer will be preferable to acquire further accumulation of TIL at tumor sites in the liver.
