Complement system and IgG subclasses in the patients with diffuse panbronchiolitis (DPB) and chronic obstructive pulmonary disease (COPD)

Hideki Onodera; Shuhei Takemura; Masako Deguchi; Masahiro Ueda; Mariko Okaya; Kunio Yanagida; Wataru Fukuda; Masayuki Okamoto; Yoshihiro Kasamatsu; Shigeru Sugino; Motoharu Kondo; Hiroshi Hara; Hideo Hayashi; Tadanao Ozeki

doi:10.2177/jsci.12.591

Hideki Onodera, Shuhei Takemura, Masako Deguchi, Masahiro Ueda, Mariko Okaya, Kunio Yanagida, Wataru Fukuda, Masayuki Okamoto, Yoshihiro Kasamatsu, Shigeru Sugino, Motoharu Kondo, Hiroshi Hara, Hideo Hayashi, Tadanao Ozeki

Author information

Hideki Onodera
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Shuhei Takemura
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Masako Deguchi
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Masahiro Ueda
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Mariko Okaya
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Kunio Yanagida
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Wataru Fukuda
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Masayuki Okamoto
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Yoshihiro Kasamatsu
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Shigeru Sugino
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Motoharu Kondo
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Hiroshi Hara
Department of Internal Medicine, Kyoto Second Red Cross Hospital
Hideo Hayashi
Department of Internal Medicine, Kyoto Second Red Cross Hospital
Tadanao Ozeki
Department of Internal Medicine, Kyoto Second Red Cross Hospital

Keywords: diffuse panbronchiolitis, chronic obstructive pulmonary disease, complement system, immunoglobulins, immunoglobulin G subclasses

JOURNAL FREE ACCESS

1989 Volume 12 Issue 6 Pages 591-598

DOI https://doi.org/10.2177/jsci.12.591

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Abstract

This study was aimed to grasp the inflammatory characteristics of DPB and COPD, by measuring the serum protein levels of the immunoglobulins, immunoglobulin G subclasses, complement components and complement hemolytic activities. In spite of the small fluctuation of CH 50, CHT 1/2% and the serum protein levels of the complement components, ACH 50 showed high units in the patients with DPB. These facts suggested both of the high activation and the increase of the suppresive factors without the complement inhibitor proteins on the alternative complement pathway in the patients with DPB. There were no differences in the levels of the immunoglobulins and immunoglobulin G subclasses between the patients with DPB and COPD

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