Abstract
When heaat-killed Propionibacterium acnes (P. acnes) is intravenously injected into mice, a remarkable infiltration of mononuclear cells, mainly macrophages, in the liver tissue is observed a week later, and when lipopolysaccharide (LPS) is additionally injected into these mice, massive hepatic cell necrosis is induced. In order to clarify the mechanism by which P. acnes causes the infiltration of monomuclear cells in the liver tissue, various fractions of P. acnes were injected into mice and their effects were studied. As a result, when the phenolwater extract of P. acnes obtained by fractionation with the Sepharose 6 B column was injected, the infultration of mononuclear cells was observed, and massive hepatic cell necrosis was subsequently induced in these mice by the injection of LPS.
