Abstract
The effect of IFN-γ on mouse IgG 1 CD 3 monoclonal antibody (VIT 3 b)-induced proliferation of peripheral blood mononuclear cells (PBMC) was examined by determinants with 3H-thymidine uptake.
In the presence of IFN-γ, VIT 3 b-induced proliferation was enhanced and this effect was more prominent in cells with lower responsiveness to VIT 3 b. However, the maximum enhancement by IFN-γ was about 300% of that in the absence of IFN-γ. VIT 3 b-induced proliferation depended on the concentration of monocytes, but even with less than 5% monocytes, enhancement by IFN-γ was observed.
The effect of IFN-γ was lower in patients with ALL than in healthy adults.
