Abstract
We report a 27-year-old female with systemic lupus erythematosus (SLE) and autoimmune hemolytic anemia (AIHA) with a history of pure red cell aplasia (PRCA) 8 years before. The patient was admitted to our hospital because of arthralgia, myalgia, fever and general fatigue on March 30, 1988. She was diagnosed as SLE with AIHA as a result of laboratory examinations which revealed anemia (Hb 6.6g/dl), leukocytopenia, presence of LE cells, high levels of anti-DNA and anti-nuclear antibodies, increased urine urobilinogen, positive Coomb's test and decreased level of haptoglobin. The etiology of PRCA had been attributed to the inhibitory effect of T-lymphocytes on the differentiation of erythroid progenitors rather than humoral factors. Thus, it was of great interest that immunologically different type of anemias developed with a time lag of 8 years in this case.
