Abstract
A case of Sjögren's syndrome complicated mainly with interstitial pneumonia in which high dose methylprednisolone therapy was effective was reported. A 60-year-old woman has been complaining of oral sicca syndrome, exertional dyspnea and general fatigue since early spring in 1990. Fine crackeles were audible and acceleration of ESR, hypoxia and restrictive ventilatory disorder were observed and a chest X-ray film showed “ground glass” shadows at bilateral lower lung fields. The diagnosis of Sjögren's syndrome with interstitial pneumonia was comfirmed by the presence of keratoconjunctivitis and also by lip and lung biopsy. Interstitial pneumonia was responsive to high dose methylprednisolone therapy in the present rare case which was characterized mainly by severe respiratory symptoms. And high dose methylprednisolone therapy was thought to be effective for these patients.
