1992 Volume 15 Issue 1 Pages 13-19
Urinary autoantibodies, focussing on immunoglobulin G (IgG), and various autoantibody activities, were investigated. There were significant correlation between urinary ANA titers and urinary IgG levels (p<0.001), and between urinary and serum ANA titers (p<0.001). Patients with speckled staining pattern of serum ANA showed higher frequencies in the appearance of urinary ANA (p<0.01).
Using ELISA, patients with anti-DNA antibody and Anti-Sm antibody were investigated. We could find a significant difference between the ratio of urinary anti-DNA and that of anti-Sm antibodies (p<0.01).
Urinary ANA may be unsuitable as a indicator of routine diagnosis for early renal involvement, but seems to reflect indirectly to the potentiality of renal trapping of antibodies.
