1992 Volume 15 Issue 2 Pages 142-147
This study was undertaken to clarify the significance of anticentromere antibody (ACA) in various diseases. Among these patients, Raynaud's phenomenon, arthritis, subcutaneous calcinosis, esophageal dysmotility, telangiectasia, Sjögren's syndrome, sclerodactyly and swollen hands were found in 15, 13, 11, 6, 4, 3 and 1 of 18 ACA positive patients respectively. In the 18 sera with ACA, rheumatoid factor (RF), anti-M 2 antibody (A-M 2), anti-mito-chondrial antibody (AMA), anti-microsome antibody (AMiA), anti-platelet antibody (APL), anti-smooth muscle antibody (ASMA) and anti-DNA antibody (A-DNA) were found in 6, 5, 4, 3, 3, 2 and 1 sera respectively. ACA was found to distribute not only in patients with collagen diseases but also in patients with primaly biliary cirrhosis (PBC). Eight ACA positive patients were also examined for HLA antigens. HLA-B 51 (5) and/or DRw 8 were highly detected. In two patients with PBC and CREST (Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, Telangiectasia) syndrome, HLA-DR 9 antigen was detected.
