Immunoglobulin therapy to patients with serious lung infection Studies on complement activation and complement fragments

Hideki Onodera; Shuhei Takemura; Yosihiro Kasamatsu; Syoji Tsujimoto; Risa Nakahara; Naoko Ichio; Takashi Doi; Masayuki Okamoto; Kunio Yanagida; Wataru Fukuda; Mariko Tanaka; Masako Deguchi; Masahiro Ueda; Atsuo Tanaka; Shigeru Sugino; Motoharu Kondo

doi:10.2177/jsci.15.346

Hideki Onodera, Shuhei Takemura, Yosihiro Kasamatsu, Syoji Tsujimoto, Risa Nakahara, Naoko Ichio, Takashi Doi, Masayuki Okamoto, Kunio Yanagida, Wataru Fukuda, Mariko Tanaka, Masako Deguchi, Masahiro Ueda, Atsuo Tanaka, Shigeru Sugino, Motoharu Kondo

Author information

Hideki Onodera
Division of Pulmonary Disease, Kyoto Prefectural Yosanoumi Hospital
Shuhei Takemura
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Yosihiro Kasamatsu
Division of Pulmonary Disease, Kyoto Prefectural Yosanoumi Hospital
Syoji Tsujimoto
Division of Pulmonary Disease, Kyoto Prefectural Yosanoumi Hospital
Risa Nakahara
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Naoko Ichio
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Takashi Doi
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Masayuki Okamoto
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Kunio Yanagida
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Wataru Fukuda
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Mariko Tanaka
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Masako Deguchi
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Masahiro Ueda
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Atsuo Tanaka
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Shigeru Sugino
First department of Internal Medicine, Kyoto Prefectural University of Medicine
Motoharu Kondo
First department of Internal Medicine, Kyoto Prefectural University of Medicine

Keywords: lung infection, immunoglobulin therapy, complement system, complement fragments

JOURNAL FREE ACCESS

1992 Volume 15 Issue 4 Pages 346-354

DOI https://doi.org/10.2177/jsci.15.346

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Abstract

Effects of immunoglobulin (IG) therapy on complement system was studied on 11 patients with serious lung infection. Complement hemolytic activities (CH 50 and ACH 50), complement profile and complement fragments (ic 3 b, Bb and C 4 d) were investigated in peripheral blood time proceedingly.
ACH 50, factor B, C 3 and C 9 decreased by IG therapy. Bb increased early, and iC 3 b increased lately. CH 50 and C 4 d showed no differences. Those results clarified IG therapy accelerated the activity of alternative complement pathway in patients with serious lung infection. An experiment in vitro comfirmed IG had direct activation to factor B. Those facts suggested that biological significance of IG therapy were present in both efficacious bacteriolysis with complement and adequate modification to complement system. This study also present the necessity to identify biological function of Bb and iC 3 b.

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