Abstract
Familial cases of HLA-B 27 associated spondyloarthlopathy were reported.
A 54-year-old male visited our hospital with the symptoms of ankle and wrist joints pain. He had been suffering from lumbago for 34 years, and uveitis for 7 years. The titer of antibody for Chlamydia trachomatis was slightly elevated. The X-ray examination revealed the bilateral sacroiliitis, squaring of the lumbar spine, syndesmophyte formation of the spine and enthesopathy. He was diagnosed as having ankylosing spondylitis (AS).
The son of this patient, 25-year-old male, was consulted to our hospital with the complaints of knee joint pain and lumbago. He had been suffering from non-gonococcal urethritis for three months before the onset of the articular symptoms. Laboratory findings revealed the elevation of ESR and CRP, and negative rheumatoid factor. Unilateral sacro-iliitis was found on X-ray film. He was diagnosed as having Reiter's syndrome.
Both cases were HLA-B 27 positive. This is the first report on the familial cases of AS and Reiter's syndrome in Japan.
