Pre-and Post-operative cytokines in patients with gallbladder stone

Abstract

Serum levels of cytokines including tumor necrosis factor (TNF-α), interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage-colony stimulating factor (GM-CSF) were examined in patients with gall bladder stone before and after operation Serum level of each cytokine showed different time course from each otehr after operation. Time course of serum levels of cytokines expect for GM-CSF had two peaks. The first peak for TNF-α, IL-1α, IL-1β, or IL-6 was observed at 15, 18, 21, or 24 hrs after operation, respectively. The second peak for each of them was 2, 3, 5, or 7 days after operation, respectively. The time course for GM-CSF showed that the serum level remained within normal during the first 24 hrs after operation and reached the peak 3 days after. The serum levels of these cytokines at their peaks were higher than those in control sera.
WBC and CRP were also examined in patients. The time course of WBC or CRP showed one peak at 24 hrs or at 2 days after operation and reached the peak 3 days after. The serum levels of these cytokines at their peaks were higher than those in cotrol sera.
WBC and CRP were also examined in patients. The time course of WBC or CRP showed one peak at 24hrs or at 2 days after operation, which was between the first and the second peaks in the time course of serum cytokine levels.
These data suggest that the production of these cytokines is closely related to surgical infection and recovery from that, and imply that they influence each other.