Abstract
To study the effects of eicosapentaenoic acid (EPA) on the surface markers of peripheral lymphocyte, 200g of sardine was loaded daily to 12 healthy subjects with or without additional intake of 1.8g of EPA for 2 weeks. Fish diet resulted in a daily intake of 3.9g EPA. Serum concentration of EPA increased from 17.5±7.2μg/ml (mean±SD) to 195.0±53.9 in the group with fish diet (n=6) and it increased from 19.5±4.2 to 277.2±24.8 in the group with fish diet and additional EPA (n=6). In each groups, CD 4+ cells with IL-2 receptor and HLA-DR were increased and CD 8+ cells with T cell receptor were decreased. In the group with fish diet, CD 8+ cells with HLA-DR were increased. These results suggest that the load of EPA may influence the surface markers of lymphocyte in human.
