Activation of complement during hemodialysis

Yoshio Nagake; Tetsuki Amano; Jun Wada; Hikaru Sugimoto; Kenji Kawabata; Kenichi Shikata; Hirofumi Makino; Zensuke Ota

doi:10.2177/jsci.18.138

Yoshio Nagake, Tetsuki Amano, Jun Wada, Hikaru Sugimoto, Kenji Kawabata, Kenichi Shikata, Hirofumi Makino, Zensuke Ota

Author information

Yoshio Nagake
The Third Department of Internal Medicine, Okayama University Medical School
Tetsuki Amano
The Third Department of Internal Medicine, Okayama University Medical School
Jun Wada
The Third Department of Internal Medicine, Okayama University Medical School
Hikaru Sugimoto
The Third Department of Internal Medicine, Okayama University Medical School
Kenji Kawabata
The Third Department of Internal Medicine, Okayama University Medical School
Kenichi Shikata
The Third Department of Internal Medicine, Okayama University Medical School
Hirofumi Makino
The Third Department of Internal Medicine, Okayama University Medical School
Zensuke Ota
The Third Department of Internal Medicine, Okayama University Medical School

Keywords: hemodialysis, dialyzer, hemodialysis leukopenia, complement, soluble membrane attack complex (S-MAC)

JOURNAL FREE ACCESS

1995 Volume 18 Issue 2 Pages 138-145

DOI https://doi.org/10.2177/jsci.18.138

Details

Abstract

In hemodialysis using 3 types of dialysis membrane materials [regenerated cellulose (RC), cellulose triacetate (CTA), and polysulfone (PS)], activation of the complement, reduction of white blood cells, and variation of vitronectin (VN) were observed.
RC membrane caused a significant reduction of white blood cells and elevations of Bb and soluble membrane attack complex (S-MAC), indicating a strong activation of the alternative complement pathway. Especially, the increase of S-MAC persisted for a long time during hemodialysis. Because reduction of VN was transient, it was assumed that the S-MAC escaping removal by VN receptors might have persisted in the circulation. These findings suggested that S-MAC would become useful as an index for evaluating biocompatibility of various artificial organs including dialysis membranes.

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