Abstract
A 63-year-old male was admitted to our hospital because of fever up, systemic lymphadenopathy and skin eruption. On admission, a peripheral blood examination showed a hemoglobin concentration of 10.1g/dl, a reticulocyte ratio of 42‰, an undetectable haptoglobin concentration below 10ng/dl, LDH of 558IU/l and strong positive results of direct/indirect Coombs test showed the existence of auto-antibodies. These data indicated autoimmune hemolytic anemia (AIHA). The skin biopsy was done and revealed an allergic dermatitis, since systemic skin eruption was accompanied by IgE concentration of 14300IU/ml and eosinophilia (14%). Immunoblastic lymphadenopathy-like T cell lymphoma was diagnosed on the lymph node biopsy. Biweekly CHOP-E therapy obtained improvement of skin eruption, lymphadenopathy, AIHA and hypergammaglobulinemia (including IgE). These findings suggest that T type lymphoma cells produced high concentration (652pg/ml) of IL-2, enhancing immune reactions and activating B cell functions, such as an allergic dermatitis and AIHA.
