Abstract

The large lymphocytes of peripheral blood increased in patients with autoantibodies and reduced in patients with the cancer. They were rich in azur granules, PAS granules, acid phosphatase granules and β-glucuronidase granules. They had the well developed mitochondria, many ribosomes and central dense bodies. They had a lot of microvilli on their surface membrane. Most of them were null lymphocytes and they contained no Tγ. They did not develop the immunoglobulin producing cells by the PWM stimulation. They increased the development of immunoglobulin producing cells from the normal blood B lymphocytes by the PWM stimulation. Their increasing effect on the development of immunoglobulin producing cells was not influenced by SLE lymphotoxin. These facts suggest that their effect might be due to the helper effect.