Immunological studies on the immunoblastic lymphadenopathy

Abstract

A marked decrease of T lymphocytes and Tγ was demonstrated in 8 patients with IBL. Null lymphocytes increased makedly in IBL. Null lymphocytes were present in the Fr I fractionated by gumi accaci density gradient centrifugation of blood lymphocytes. The PHA blastoid transformation of IBL blood lymphocytes slightly decreased. A marked decrease of Ts was demonstrated in blood and lymphnode lymphocytes in IBL. The development of cIg⁺ cells by PWM stimulation from IBL lymphnode B lymphocytes was demonstrated, but it was resistant to the regulation of normal Ts. No lymphocytotoxin was demonstrated in IBL serum. The induction of Ts activity by the ConA activation of IBL lymphocytes was markedly decreased. Null lymphocytes of Fr I showed the helper effect to the development of clg⁺ cells from normal B lymphocytes by the PWM stimulation.