1982 Volume 5 Issue 4 Pages 308-313
Two cases of Kimura's disease and review of the literature were reported. Both patients had multiple tumor-like swellings in the subcutaneous regions, lichen amyloidosis on the lower extremities, mild leukocytosis with marked peripheral blood eosinophilia and hyperimmunoglobulinemia E. They were diagnosed by biopsy evidence of granulomas. Subcutaneous granulomas were composed of hyperplastic lymphoid tissue which contained well-developed lymphoid follicles and infiltrates of eosinophils. In patient 1., granulomas were occurring on the temporal, preauricular, upper eye-lid regions and also in the oral cavity; the last one was the extremely rare site. He had a surgical excision of the temporal tumor. After the operation, the level of the peripheral blood eosinophilia was slightly improved but that of the serum IgE was unchanged. Now he has been treated with Inteban at the outpatient clinic and the hyperimmunoglobulinemia E state is improved, although the granulomas are yet present. In patient 2., granulomas were occurring on the occipital, buccal, cevical and submandibular regions and they were tend to be increased in size without treatment. So he has been taken Inteban for these 20 years and the clinical feature was almost stable. However, the serum IgE level was not decreased after Inteben treatment in this case.