The effect of monocytes and T cells pretreated with aggregated IgG on generation of concanavalin A induced suppressor T cells

Abstract

The present studies showed that monocytes are necessary for the generation of Con A-induced suppressor T cells.
Furthermore, the pokeweed mitogen response of B cells and mixid lymphocytes reaction were suppressed strongly by suppressor T cells which had been induced by Con A in the presence of monocytes at a concentration of 5-10%.
The generation of Con A-induced suppressor T cells was blocked when these T cells were precultured with monocytes pretreated with aggregated IgG.
In contrast, an enhancement of suppressor cell generation was observed when the T cells were treated with aggregated IgG before Con A activation.
The monocytes of patients with systemic lupus erythematosus and rheumatoid arthritis contributed to the generation of Con A-induced suppressor T cells to a less degree.