Abstract
On human blood cell membranes there are several kinds of complement receptors which have important roles to initiate each cell's function. Recently, high incidence of defective reactivity as well as low number of complement receptors for C3b (CR1) on erythrocytes was found in patients with systemic lupus erythematosus (SLE), which is thought to be inherited.
The study was designed to investigate the incidence of defective reactivity of CR1 on erythrocytes in various diseases by immuneadherence hemagglutination (IAHA) using aggregated human IgG (AHG). In normal controls, 21 out of 312 (6%) revealed defective CR1 reactivity, and there was no difference in the incidence between female (11/157, 7%) and male (10/155, 6%). Among various diseases examined, significantly high prevalence of defective reactivity of CR1 on erythrocytes was seen in SLE (22/30, 73%) and malignancy of hematopoietic system, especially in acute myelogenous leukemia (AML) (6/11, 55%).
