Polymorphonuclear leukocyte C3b receptors (CRl) and its relationship to the expressin of erythrocyte CRl in patients with systemic lupus erythematosus

Masako Deguchi; Shuhei Takemura; Masahiro Ueda; Haruo Miyagawa; Norimasa Yoshida; Yasumasa Furukawa; Koichi Nishida; Haruki Kato; Toshikazu Yoshikawa; Shigeru Sugino; Motoharu Kondo

doi:10.2177/jsci.8.123

Masako Deguchi, Shuhei Takemura, Masahiro Ueda, Haruo Miyagawa, Norimasa Yoshida, Yasumasa Furukawa, Koichi Nishida, Haruki Kato, Toshikazu Yoshikawa, Shigeru Sugino, Motoharu Kondo

Author information

Masako Deguchi
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Shuhei Takemura
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Masahiro Ueda
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Haruo Miyagawa
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Norimasa Yoshida
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Yasumasa Furukawa
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Koichi Nishida
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Haruki Kato
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Toshikazu Yoshikawa
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Shigeru Sugino
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Motoharu Kondo
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine

Keywords: systemic lupus erythematosus (SLE), C3b receptor (CRl), erythrocyte, polymorphonuclear cell (PMN), immune adherence hemagglutination (IAHA)

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1985 Volume 8 Issue 2 Pages 123-126

DOI https://doi.org/10.2177/jsci.8.123

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Abstract

The defective C3b receptor (CRl) activity on erythrocytes is frequently seen in systemic lupus erythematosus (SLE) and leukemia. Defective CRl activity on erythrocytes in SLE is thought to be inherited as an autosomal codominant manner. CRl exsists on cell types other than erythrocytes, including neutrophils, eosionphils, monocytes, macrophages, B and some T lymphocytes, mast cells, and glomerular podocytes. The relationship of the expression of erythrocytes with other cell types is unclear. In this study we investigated the relationship of CRl activity between erythrocytes and polymorphonuclear leukocytes (PMN).
The CRl activity on erythrocytes was measured by immune adherence hemagglutination (IAHA) using aggregated human IgG sensitized erythrocytes and guinea pig complement. Patients with SLE were grouped into two, group 1, those who possess CRI activity on erythrocytes, and group 2, those who showed defective CRl activity on erythrocytes.
The activity of CRl on PMN was studied by; 1) rosette formation of PMN by EA (IgM) C3b, and 2) inhibition test of IAHA using EA (IgM) C3b lysate by PMN.
Compared with healthy controls, SLE patients revealed significantly decreased rosette formation.

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