Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
Two cases of Mesangiocapillary Glomerulonephritis that show defective C3b receptor on erythrocyte
Tetsuro IkezawaHiroyuki OhiMasato SekiTakayuki FujitaHiroyuki KojimaShizuhiko WatanabeNoriyuki NawaYasuhide MizutaniMichinobu Hatano
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1986 Volume 9 Issue 2 Pages 128-133

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Abstract
We examined CR 1 on the red blood cell in the patients with primary glomerulonephritis using immune adherence haemagglutination (IAHA) method, and we found 2 patients of Mesangiocapillary Glomerulonephritis (MCGN) with CR 1 deficiency on the red blood cell. The two patients were Nephrotic syndrome. One patient's serum was found to contain anti Nuclear antibody (ANA), and C3 Nephritic factor (C3NeF) causing hypocomplementaemia was detected in the other patient. The deficiency of CR 1 was found in one of the parents of both these MCGN patients. It is thought that the cause of CR 1 deficiency on the red blood cell is hereditary and that it might be influencing the pathogenesis of these MCGN patients.
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© The Japan Society for Clinical Immunology
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