Three Cases of Cutaneous Adverse Reactions Rescued by Corticosteroid Pulse Therapy Administered in the Early Phase

Abstract

　Toxic epidermal necrolysis (TEN) , Stevens-Johnson syndrome (SJS) , and drug-induced hypersensitivity syndrome (DiHS) are life-threatening severe cutaneous adverse reactions (SCARs) . Corticosteroids have been used for such cases in Japan, and recommended as first-line treatment in the 2016 Japanese guidelines for the treatment of SJS/TEN. We have successfully treated TEN, SJS, and DiHS cases using corticosteroid pulse therapy in the early phase of the disease. Rapid improvement was observed in clinical symptoms without side effects, such as infections or sequelae such as visual disorders. We herein present each case of TEN, SJS, and DiHS with a review of corticosteroid pulse therapy in the early phase of SCARs.