2020 Volume 3 Issue 2 Pages 282-293
Stevens-Johnson syndrome（SJS）is an acute inflammatory vesiculobullous reaction of the skin and mucosa such as the ocular surface, oral cavity, and genitals. In patients with extensive skin detachment and a poor prognosis, the condition is called toxic epidermal necrolysis（TEN）. Severe ocular complications（SOC）appear in about half of SJS/TEN patients diagnosed by dermatologists. Ophthalmologists tend to report both SJS and TEN with severe ocular complications as“SJS”in a broad sense. Cold medicines, including multi-ingredient cold medications and non-steroid anti-inflammatory drugs（NSAIDs）were the main causative drugs of SJS/TEN with SOC in all SJS and TEN patients.
Cold medicine-related SJS/TEN（CM-SJS/TEN）with SOC was strongly associated with HLA-A＊02 : 06 in the Japanese populations, and significantly associated with some genes such as IKZF1 gene. As we found several HLA-SNP sets with a high odds ratio, we postulated that they may help to predict the possible development of SJS/TEN with SOC.
（日本皮膚免疫アレルギー学会雑誌, 3（2）：282-293, 2020）
