2020 Volume 3 Issue 2 Pages 326-329
An 18-year-old woman developed dyspnea and generalized urticaria necessiating emergency treatment after taking an over-the-counter medicine for a common cold. She was referred to our institute to determine the causative agent of anaphylaxis. The medicine was composed of eight ingredients, including methyl ephedrine. Each agent was examined by a prick, scratch-chamber and oral provocation test. All results were negative, except for those for methyl ephedrine. Obtaining methyl ephedrine as a single medicine is regulated. Huscode combination tablets are usually distributed as cold medicine, and those including methyl ephedrine, were examined. Dyspnea and rhinorrhea with generalized erythema were provoked 75 minutes after Huscode combination tablet administration. No symptoms were induced by the other ingredients of Huscode combination tablets. Methyl ephedrine was presumed to be the causative agent of anaphylaxis. This is the first case report of anaphylaxis due to methyl ephedrine.
(日本皮膚免疫アレルギー学会雑誌, 3(2):326-329, 2020)