Abstract
The pharmacokinetics, pharmacodynamics and safety of thymoxamine were studied in 3 healthy male subjects by intravenous injection of thymoxamine hy drochloride at doses of 2, 5 and 10mg. Each subject recieved one dose at each level, the amount increasing with each week's injection.
Each subject rested in supine position on the examination bed while the fol lowing parameters were continuously monitored for 2-3 hours: systolic blood pressure ; deep body temperature at the forehead, palm and sole ; fingertip skin temperature ; blood flow in the skin at the wrist ; ECG ; and respiratory rate.
Thymoxamine tended to lower the blood pressure and elevate the peripheral temperature. Some subjects had a warm feeling at the extremities and flushed feeling at the cheeks.
The ECG and the respiratory rate showed no significant change. The half time of this drug was found to be 83 min. The urinary excretion rate was 20.3% within 24 hours. The feces excretion rate was 2.0% within 72 hours. No side effect noted in laboratory tests were observed during this study.
