Abstract
In a comparative study with the use of a signgle-blind, Latin square design, piretanide was given orally at three doses to 8 healthy male volunteers.
(1) The diuretic action of piretanide began within one hour after administration and lasted five or six hours.
(2) There was a close correlation after piretanide between dose and diuretic effect, while no correlation was observed between dose and the excretion of potassium and creatinine.
(3) Six mg of piretanide was as potent as 40 mg of furosemide in terms of diuresis, sodium and chloride excretion.
(4) Piretanide was well-tolerated.
