Clinical Efficacy of Furosemide-Retard (Hoe 058 R) in Essential Hypertension ADouble-Blind Controlled Study with Trichlormethiazide

Teiryo MAEDA; Yoshiaki MASUYAMA; Shozo KOSHIKAWA; Teizo SANJYO; Akio EBIHARA; Tsuneji NAGAI; Teizo ITO; Takao IKEDA; Masashi ISHIDA; Tadashi ITOKAWA; Keizo KOIDE; Tetsugo SAKATA; Takuo SASAOKA; Masayoshi SHIBAGAKI; Toshiro SHIBATA; Katsutaka SETA; Sho TANAKA; Masao TAKAHASHI; Toshio HARADA; Saburo HIDAKA; Ippei FUJIMORI; Yo YAMAGATA; Yoshiji YAMANE; Osamu YOKOTA

doi:10.3999/jscpt.10.425

Clinical Efficacy of Furosemide-Retard (Hoe 058 R) in Essential Hypertension

ADouble-Blind Controlled Study with Trichlormethiazide

Teiryo MAEDA, Yoshiaki MASUYAMA, Shozo KOSHIKAWA, Teizo SANJYO, Akio EBIHARA, Tsuneji NAGAI, Teizo ITO, Takao IKEDA, Masashi ISHIDA, Tadashi ITOKAWA, Keizo KOIDE, Tetsugo SAKATA, Takuo SASAOKA, Masayoshi SHIBAGAKI, Toshiro SHIBATA, Katsutaka SETA, Sho TANAKA, Masao TAKAHASHI, Toshio HARADA, Saburo HIDAKA, Ippei FUJIMORI, Yo YAMAGATA, Yoshiji YAMANE, Osamu YOKOTA

Author information

Teiryo MAEDA
Dept. of Internal Medicine, Kanto Rosai Hospital
Yoshiaki MASUYAMA
Dept. of Circulation, Wakayama Medical College
Shozo KOSHIKAWA
Dept. of Internal Medicine, Fujigaoka Hospital of Showa University
Teizo SANJYO
Dept. of Internal Medicine, Tokyo Teishin Hospital
Akio EBIHARA
Dept. of Clinical Pharmacology, School of Medicine, Jichi Medical School
Tsuneji NAGAI
Dept. of Pharmacy, Hoshi Pharmaceutical College
Teizo ITO
Dept. of Circulation, Self-Defense Forces Central Hospital
Takao IKEDA
Dept. of Internol Medicine, Kanto Teishin Hospital
Masashi ISHIDA
1st. Dept. of Internal Medicine, St. Marianna Ika Daigaku
Tadashi ITOKAWA
2nd. Dept. of Internal Medicine, School of Medicine, Showa University
Keizo KOIDE
Dept. of Circulation, National Oji Hospital
Tetsugo SAKATA
Dept. of Internal Medicine, Tokyo Rosai Hospital
Takuo SASAOKA
Dept. of Internal Medicine, Yokosuka Kyosai Hospital
Masayoshi SHIBAGAKI
Dept. of Internal Medicine, Kawasaki Municipal Ida Hospital
Toshiro SHIBATA
Dept. of Internal Medicine, Hitachi Seisakusho Totsuka Hospital
Katsutaka SETA
Dept. of Internal Medicine, Central Hospital of Health Insurance
Sho TANAKA
2nd. Dept. of Circulation, Japanese Red Cross Medical Center
Masao TAKAHASHI
Dept. of Internal Medicine, Omori Red Cross Hospital
Toshio HARADA
Dept. of Internal Medicine, Kodaira Memorial Hitachi Hospital
Saburo HIDAKA
Dept. of Internal Medicine, Kawakita Hospital
Ippei FUJIMORI
Dept. of Internal Medicine, Kawasaki Municipal City Kawasaki Hospital
Yo YAMAGATA
Dept. of Nephrology, Hitachi General Hospital
Yoshiji YAMANE
Dept. of Internal Medicine, Tokyo Kosei Nenkin Hospital
Osamu YOKOTA
Dept. of Internal Medicine, Omiya Red Cross Hospital

Keywords: Hoe 058 R, Trichlormethiazide, Double-blind study, Essential hypertension

JOURNAL FREE ACCESS

1979 Volume 10 Issue 3 Pages 425-447

DOI https://doi.org/10.3999/jscpt.10.425

Details

Abstract

The antihypertensive effect and usefulness of Hos 058 R (H) were compared with those of trichlormethiazide (T) as a control drug under double-blind conditions.
The following results were obtained.
1. Antihypertensive effect
There was no significant difference between Hoe 058 R and trichlormethiazide in the global evaluation of antihypertensive effect. The effects on both systolic and mean blood pressure were significantly greater with T than with II However, there was no significant difference in the effect on diastolic pressure.
2. Laboratory data
The decrease in the serum Cl- level in 8th week was significantly greater in the T-group than in the H-group.The BUN elevation in the T-group was significantly higher than in the H-group.
3. Side effects
The incidence of pollakiuria and polyuria was 7.1% (6/85) in the H-group and 3.7% (3/82) in the T-group.This difference was not significant. No other note-worthy side effects occurred.
4. Usefulness
There was no significant difference between the two groups.

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