Diuretic Activity of Piretanide

Intravenous Dose Equivalence of Piretanide Injection to Bumeta-nide Injection in Liver Cirrhosis Patients

Abstract

The diuretic activity of piretanide injection was compared with that of bumetanide injection in 6 patients with liver cirrhosis. Drugs were allotted according to a single-blind Latin square design. The following conclusions were obtained:
1. For each drug the diuretic effect reached a maximun within 2 hours after intravenous administration, and in 4 hours the effect largely disappeared .
2. Six mg of piretanide was found to be almost equivalent to 0.5 mg of bumetanide with respect to the effects upon urinary volume and Na⁺ excretion.
3. The electrolyte excretion pattern obtained with piretanide was similar to that of bumetanide.
4. No changes in symptoms, abnormal laboratory data, or untoward effects were noted with either drug.