Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601
Proposal of Method for Usefulness-judgement of Drugs on Chronic Aggressive Hepatitis
Jutaro OKADA
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1981 Volume 12 Issue 1 Pages 51-60

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Abstract
In double blind tests, the results are usually expressed qualitively by physician's judgements. In order to express those results quantitatively and to avoid the personal deviation between physicians, the rate coefficient “b” is proposed under the assumption of exponential transition of clinical measurements, e. g., GOT, GPT, and etc. It is confirmed that “b” is distributed normally and its standard deviations are the same in tiopronin-group and placebo-group.Using “b”, tiopronin is judged significantly useful for outpatients, but not so useful for inpatients and the method for usefulness-judgement of drugs on Chronic Aggressive Hepatitis are proposed. These methods are checked by the data of previous double-blind test and its validity is recognized.
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© The Japanese Society of Clinical Pharmacology and Therapeutics
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