Abstract
The diuretic effect and safety of piretanide injection were compared with that of furosemide injection in 66 patients with liver cirrhosis and 8 with other disease by means of a double blind intergroup comparison. The following conclusions were obtained.
1) No significant differences were observed in the degree of general improvement and usefulness in liver cirrhosis between the two groups, nor were there any significant differences between the two groups when all 74 cases were evaluated.
2) 0-4 Hour urine volume and urinary excretion of Na+ and Cl- in the piretanide group showed significantly larger increases than the furosemide group.However there was no significant difference in the increase of K+ excretion.
3) Uric acid excretion on the 2nd day of treatment period and total uric acid excretion during the 3 days of the treatment period were both signicicantly larger in the piretanide group than in the furosemide group.
