Comparative Study of Dothiepin and Amitriptyline in Normal Volunteers

Abstract

The adverse reactions due to single doses of dothiepin 25mg and amitriptyline 25mg were compared in healthy volunteers in double blind, coss-over fashion. The subjects were 7 young (21 to 25 yr of age, average are: 22.7) men. Self-rating, and physiolo-gical and psychological measures were applied, and experiments were performed for 24 hrs after the administrations. Dothiepin 25mg decreased critical flicker frequency and reduced salivary rates significantly less than amitriptyline 25mg. The values of diastolic blood pressure at sitting position were lower after the administrations of dothiepin 25mg than amitriptyline 25mg. The method of evaluating adverse drug reaction was discussed here.