Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Online ISSN : 1882-8272
Print ISSN : 0388-1601
ISSN-L : 0388-1601
Effects of Dilazep Dihydrochloride on the Oxygen Dissociation Curve of the Hemoglobin
In Vitro and In Vivo Studies
Naoki TANIGUCHIHirohiko FURUIKazunobu YAMAUCHIIwao SOTOBATA
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1983 Volume 14 Issue 2 Pages 357-363

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Abstract
The present study was undertaken to estimate in vitro and in vivo effects of dilazep on the hemoglobin-oxygen dissociation curve of venous blood from 16 healthy men.
Dilazep (5×10-6 to 5×10-4M) significantly shifted the oxygen dissociation curve of the hemoglobin to the right but did not affect the 2, 3-DPG contents on incubation of blood samples for 2 to 4 hours with the drug. In vivo administration of dilazep (300mg/day for one week), however, produced a significant shift of the curve to the left. This leftward shift was accompanied with a tendency for contents of 2, 3-DPG to decrease without a significant changes in HbAIC levels. There were no changes observed in P50, 2, 3-DPG and HbAlc levels with a lower dosage of dilazep (150 mg/day for oneweek).
These findings suggested that the increased oxygen binding to hemoglobin induced by dilazep in vivo resulted from a probable increase in systemic oxygen delivery due to its vasodilating effects.
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© The Japanese Society of Clinical Pharmacology and Therapeutics
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