Study of Theophylline Pharmacokinetics in Pediatric Bronchial Asthma Patients

Relationship between Change in Osmotic Resistance of Erytrocyte Membrane and Forecast Adverse Reaction

Abstract

Theophylline (TP) plasma concentration and change in the osmotic resistance of erythrocyte membrane, following oral administration of aminophylline, were studied in ambulatory bronchial asthmatic children.
The osmotic resistance of erythrocyte membrane was measured by coil planet centrifuge system.
In normal adults and asthmatic children, hemolysis starting point was shifted to the lower side of osmotic pressure, and the osmotic resistance of erythrocyte membrane were increased after administration of TP.
In patients with past adverse reactions of TP derivation, the time to the peak of the osmotic resistance were at the same time or shorter than that to the peak plasma concentration.
It suggested that relationship between the peak TP plasma concentration and change in osmotic resistance might be enable to forecast adverse reaction.