Double-blind Controlled Study of Cyclazocine and Pentazocine in the Treatment of Post-surgical Pain

Abstract

A double-blind controlled study was conducted in order to compare the analgesic effects of cyclazocine (0.3 and 0.5 mg) and pentazocine (15 and 30 mg) administered intramuscularly. The subjects were 363 post-operative patients having severe pain following abdominal surgery with halothane/N₂O, enflurane/N₂O or neuroleptanesthesia.
Pain intensity and sedation scores were recorded at 0.5, 1, 3 and 6 hours after injection. of 363 patients, 346 were subjected to general analysis and 17 to safety analysis only.
Cyclazocine 0.5 mg and pentazocine 30 mg were superior to pentazocine 15 mg in analgesic effect; statistically significant differences (p<0.05) in analgesic efficacy were found between cyclazocine 0.5 mg and pentazocine 15 mg; and between pentazocine 30 mg and pentazocine 15 mg.
In the overall utility rating, the rates of usefulness of cyclazocine 0.3 and 0.5 mg and pentazocine 15 and 30 mg were 67.8, 80.7, 60.0 and 80.2% respectively. The contrasts in clinical usefulness of cyclazocine 0.5 mg as well as pentazocine 30 mg against pentazocine 15 mg were statistically significant (p<0.05).