The Influence of BKU (Urapidil Retard Capsules) on Diurnal Variations of Blood Pressure in Patients with Essential Hypertension

Tadanao TAKEDA; Yoshiyasu IKUNO; Yoshihiro KANEKO; Hisakazu YASUDA; Kaoru YOSHINAGA; Yoshiaki INAGAKI; Masao ISHII; Koichi TANIGUCHI; Yasushi MIZUNO; Tatsuo KOKUBU; Kikuo ARAKAWA

doi:10.3999/jscpt.17.347

Tadanao TAKEDA, Yoshiyasu IKUNO, Yoshihiro KANEKO, Hisakazu YASUDA, Kaoru YOSHINAGA, Yoshiaki INAGAKI, Masao ISHII, Koichi TANIGUCHI, Yasushi MIZUNO, Tatsuo KOKUBU, Kikuo ARAKAWA

Author information

Tadanao TAKEDA
The First Department of Internal Medicine, Osaka City University Medical School
Yoshiyasu IKUNO
The First Department of Internal Medicine, Osaka City University Medical School
Yoshihiro KANEKO
2 The Second Department of Internal Medicine, Yokohama City, University
Hisakazu YASUDA
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
Kaoru YOSHINAGA
The Second Department of Internal Medicine, Tohoku University School of Medicine
Yoshiaki INAGAKI
The Third Clinical Department of Internal Medicine, Chiba University School of Medicine
Masao ISHII
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Koichi TANIGUCHI
The Second Department of Internal Medicine, Tokyo Medicaland Dental University
Yasushi MIZUNO
Department of Internal Medicine, Fujita Gakuen University School of Medicine
Tatsuo KOKUBU
The Second Department of Internal Medicine, Ehime University School of Medicine
Kikuo ARAKAWA
10 The Second Department of Internal Medicine, School of Medicine, Fukuoka University

Keywords: urapidil, diurnal variations, essential hypertension

JOURNAL FREE ACCESS

1986 Volume 17 Issue 2 Pages 347-358

DOI https://doi.org/10.3999/jscpt.17.347

Details

Abstract

The Influence of BKU (urapidil retard capsules) on diurnal variations of bloodpressure was investigated in 25 patients with essential hypertension. The drug wasgiven at 60-120 mg daily in divided doses for a period of 5-32 days (average 11.1days). Blood pressure and heart rate were measured at 9 time-points from 7: 00 a.m.to 7: 00 a.m. in the next morning before and after treatment.
Blood pressure was reduced at each time-point, but diurnal variations of bloodpressure was not affected by administration of BKU. There was no alteration in heartrate. The drug did not cause undue effects on urine volume and body weight of thepatients. No serious side effects attributable to the drug were noted in any patients.
These results suggest that BKU twice daily may be an effective and safe drug intreating essential hypertension.

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