Pharmacokinetics of Intravenous Famotidine in Elderly Patients with and without Renal Insufficiency and in Healthy Young Volunteers

Abstract

The pharmacokinetics of famotidine were studied in 7 elderly patients with normal renalfunction, 5 elderly patients with moderate renal insufficiency, 8 anuric elderly patients, and6 healthy young volunteers after intravenous administration of a 10 mg dose .
Although the elimination half-life was not significantly different among the elderly patients with moderate renal insufficiency, the elderly patients with normal renal function, andthe young healthy volunteers, it was considerably prolonged in the anuric elderly patients .There was a good correlation between creatinine clearance estimated by their serum creatinine concentration and the elimination rate constant of famotidine (r=0.754).