Pharmacoepidemiological Study (II) New Quinolones (2)

Drug-drug Interaction between the Quinolones (Norfloxacin, Ofloxacin) and Al³⁺ and/or Mg²⁺ Containing Antacids

Abstract

In a pharmacoepidemiological study, the response to norfloxacin and ofloxacin (duration of treatment and total dose prescribed) was analyzed in order to determine whether norfloxacin and ofloxacin in combination with metal cation-containing prepara tions have an effect on the outcome of treatment.
The treatment duration and total dose prescribed were significantly greater (p<0.005, respectively ; using the Mann-Whitney test) in the patients given norfloxacin in combination with metal cation-containing agents than in those on monotherapy. However, the effects ofloxacin showed no change by combination administration with drugs containing magnesium and/or aluminum.