2000 Volume 31 Issue 6 Pages 701-704
This study was performed to determine the influence of dosing time of enalapril, an angiotensin-converting enzyme. inhibitor, on pulmonary function. Enalapril (10 mg) or placebo was given orally at 10: 00 and 22: 00 to eight healthy, nonsmoking, male adults in a randomized, double-blind crossover design. Peak expiratory flow (PEF) was determined at 16: 00 on day 1 and 04: 00 and 16: 00 on day 2. PEF at 04: 00 was significantlylower than that at 16: 00 (p<0.01). Enalapril dosed at 10: 00 or 22: 00 did not signifi cantly influence the daily variations of PEF compared to placebo. The daily variation of pulmonary function might not be influenced by a single dosing of enalapril in the morning or evening.
